Department of Biological Sciences

Larry C.H. Wang

Mailing address: Department of Biological Sciences, University of Alberta,
Edmonton, Alberta, Canada, T6G 2E9
Office Number: Z706 Bio Sciences
Email address: larry.wang@ualberta.ca
Fax address: (780) 492-1667
Phone Number: (780) 492-1276 or 492-4402

Academic degrees

• BSc: National Taiwan Normal University
• MSc: Rice University
• PhD: Cornell University

Areas of Involvement

Teaching

• Environmental Physiology
• Principles of Animal Physiology
• Vertebrate Physiology

Administration

• Member, Faculty of Science Fund Raising Committee
• Member, Biosciences Awards Committee
• Member, AHFMR Scholar Selection Committee

Professional Activities

• Elected North American Editor: Journal of Comparative Physiology
• Member, International Scientific Committee for Hiberation and Related Studies
• Member, Flavelle Medal Committee, Royal Society of Canada, 1994-97
• Elected Member of Editorial Board:
  1. American Journal of Physiology: Regulatory, Integrative, and Comparative Physiology;
  2. Cryobiology;
  3. Journal of Chinese Medicine (Republic of China);
  4. Problems of Cryobiology (USSR);
• Member, Board of Directors: Canadian Ginseng Research Foundation (non-profit)

Current Research interests

The physiology of cold: 1) Ecology, physiology and biochemistry of mammalian hibernation, 2) Physiology of hypothermia, including the establishment of animal models for prolonged survival under profoundly depressed body temperature, and 3) Mechanisms of improved cold tolerance in animals and men, including the modulation of maximum heat production in cold by nutritional and pharmacological manipulations and the strategies for prevention of accidental hypothermia in man.

Recent Publications

HK Srere, D. Belke, LCH Wang and SL Martin. “a2-Macroglobulin gene expression during hibernation in ground squirrels is independent of acute phase response. American Journal of Physiology 268 (1995): R1507-R1512.

T-F Lee , C-F Chen, LCH Wang, T-H Tsai. Modulatory effects of magnolol on potassium-stimulated 5-hydroxytryptamine release from rat cortical and hippocampal slices. Neuroscience Letters 186 (1995): 49-52.

LCH Wang, TF Lee and B Liu. Regulation of cardiac function in hibernation. In 4th International Congress of Comparative Physiology and Biochemistry, 29 ms. : 4th International Congress of Comparative Physiology and Biochemistry, Accepted for publication 8 August 1995.

B. Liu, GD Lopaschuk and LCH Wang. Improved rat heart function after low Ca2+ perfused preservation at 5oC for 18 hours. Cryobiology 31 (1994): 254-262.

Y. Cui, TF Lee and LCH Wang. Species difference in the modulatory effect of k agonist on 5-HT release from ground squirrel and rat hippocampus. Neuroscience Letters 175 (1994): 126-128.

Y. Cui, TF Lee, LI Kramarova and LCH Wang. The modulatory effects of mu and kappa opioid agonists on 5-HT release from hippocampal and hypothalamic slices of euthermic and hibernating ground squirrels. Life Sciences 53 (1993): 1957-1965.

Y. Cui, TF Lee and LCH Wang. Thermoregulatory responses following injection of 5-hydroxytrptamine into the sephtohippocampal complex in rats. Pharmacological and Biochemical Behavior 45 (1993): 935-939.

LCH Wang and TF Lee. Torpor and hibernation in mammals: metabolic, physiological and biochemical adaptations. Handbook of Physiology, Adaptation to the Environment. 69 ms. Editors MJ Fregly and CM Blatteis. New York: Oxford University Press. Accepted for publication 2 July 1993.

LCH Wang. Is endogenous opioids involved in hiberation? Life in the Cold III: Ecological, Physiological and Molecular Mechanisms, pp.297-304. Editors C. Carey, GL Florant, BA Wunder and B. Horowitz. Colorado: Westview Press. 1993.

L. Liu and LCH Wang. Regulation of cardiac cytosolic free Ca2+ at low temperature in the Richardson's ground squirrel. Life in the Cold III: Ecological, Physiological and Molecular Mechanisms, 8 galley. Editors C. Carey, GL Florant, BA Wunder and B. Horowitz. Colorado: Westview Press. Accepted for publication 2 June 1993.

SL Martin, HF Srere, D. Belke, LCH Wang and HV Carey. Differential gene expression in the liver during hibernation in ground squirrels. Life in the Cold III: Ecological, Physiological and Molecular Mechanisms, pp.443-453. Editors C. Carey, GL Florant, BA Wunder and B. Horowitz. Colorado: Westview Press. 1993.

B. Liu, LCH Wang and DD Belke. Effect of temperature and pH on cardiac myofilament Ca2+ sensitivity in rat and ground squirrel. American Journal of Physiology (Regulatory, Integrative Comparative Physiology) 264 (1993): R104-R108.

ML Jourdan, TF Lee and LCH Wang. Survival and resuscitation from hypothermia: what natural hibernation can teach us about mammalian response to hypothermia. pp. 23-44. In Clinical Applications of Cryobiology. Editors G. Grout and B. Fuller. 1992. CRC Press.

MD McArthur, ML Jourdan and LCH Wang. Prolonged stable hypothermia: effects on blood gases and pH in rats and ground squirrels. American Journal of Physiology (Regulatory, Integrative Comparative Physiology) 262 (1992): R190-R197.

LCH Wang, ZL Jin and TF Lee. Decrease in cold tolerance of aged rats caused by the enhanced endogenous adenosine activity. Pharmacology Biochemistry Behavior 43 (1992): 117-123.

HK Srere, LCH Wang and SL Martin. A central role for differential gene expression in mammalian hibernation. 89: 7119-7123. Proceedings of the National Academy of Sciences. 1992.

Faculty

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