The erythrocytic cycle of malaria can cause anemia because the infected erythrocyte is destroyed as schizogony ends and the merozoites make their exit. One strain of P. yoelli, a malaria of mice, has a rapid rate of multiplication and is non-selective about the type of erythrocyte its merozoites will penetrate. Consequently, it destroys erythrocytes faster than they are replenished and will kill the host.
This photo is a blood smear from a mouse that was near death after being infected just five days previously. Can you find any uninfected erythrocytes? The multinucleated parasite forms are schizonts.