University of Alberta

Dr. Greg G Goss > Professor

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Contact

Room: Z 512, Biological Sciences
Phone: (780) 492-2381
Fax: (780) 492-9234
Email: greg.goss@ualberta.ca

Current Research Interest

The Goss lab has two primary research interests: comparative physiology and aquatic toxicology.

Comparative Physiology of Ion transport:
My basic NSERC Discovery funded research program involves understanding the fundamental aspects of how animals move ions (primarily Na+ and Cl-) and acid-base equivalents (H+, HCO3- and NH4+) between the animal and its environment to achieve acid-base balance. We use a combination of whole animal experimentation, cell and molecular biology and system biology (-Omic) approaches to understanding this physiology. A significant amount of research also takes places each summer at the Bamfield Marine Sciences Centre

Research projects currently underway in the Goss Lab
The following are a sampling of some of the currently active research projects in the Goss lab.
1) Cloning and characterization of SLC26A anion transporters in fish tissues
2) Physiology of isolated MR cells in rainbow trout using intracellular imaging approaches.
3) The roles and regulation of the the gill V H+ ATPase in anion transport at the fish gill.
4) Intracellular pH regulation in the larval mosquito gut.

Toxicology and Toxigenomics
I currently am funded by the Alberta Ingenuity Centre for Water Research, Environment Canada and NSERC through its strategic grants program to investigate the mechanisms of toxicity of specific toxicants. We are using a combination of approaches to understanding the mechanism of toxicity of these compounds including advanced microscopy, proteomics and genomics, cellular and whole animal physiology. Of particular interest is the current research program that is developing to investigate the potential toxicity/specificity of manufactured nanomaterials. The overall goal of this research is to predict the relative toxicity of specific manufactured nanomaterials and allow for the development of solid science based guidelines for risk prediction and regulatory guidelines.

The following are a sampling of some of the currently active research projects in the Goss lab.
5) Development of proteomic techniques for use in fish toxicology
6) Measurement and toxicity of trace organics in fish tissues.
7) Metabolomics of fish blood and urine in response to nanoparticle exposure
8) Effects of nanoparticles exposure on fish ion transport function
9) Fate, distribution and effect of Si nanomaterials on zebrafish development

Research philosophy- My research philosophy is to encourage students to learn and research in areas that they find interesting. Graduate students in my lab studying under my research direction are relatively free to pursue their interests in the broad area of their research goals. I strongly encourage students to pursue opportunities for study and travel abroad through participation in international and national conferences and through the application for joint research initiatives.

If interested in pursuing graduate studies in the Goss Lab, contact me directly at greg.goss@ualberta.ca and provide a statement of research interests and a list of courses and grades obtained.

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Last Modified:2010-03-04